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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat JURNAL ILMU KEFARMASIAN INDONESIA
Widiyastuti, Lina
Fakultas Farmasi Universitas Ahmad Dahlan
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

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Formulasi dan Aktivitas Antibakteri Gel Ekstrak Daun Murbei (Morus alba L.) terhadap Staphylococcus aureus Akbar Rino Pamuladiman; Lina Widiyastuti
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.941

Abstract

Mulberry leaves (Morus alba L.) contain quercetin, a flavonoid compound with antibacterial activity against Staphylococcus aureus. For convenience, dosage accuracy, and hygiene, a gel formulation with a mixture of carbopol and propylene glycol is required. This study aimed to determine the right concentration of carbopol and propylene glycol to obtain a gel with good physical properties and antibacterial activity on Staphylococcus aureus. Mulberry leaf extract was obtained by maceration method. A factorial design method was used to optimize carbopol and propylene glycol concentrations. The parameters of gel physical properties were the viscosity, spreadability, adhesion, and pH test. The optimal area was determined by creating a contour plot of the parameters test result. Validation of the optimum formula was by comparing the prediction result to the actual research result. The data were analyzed using SPSS with a 95% confidence level. The results showed that the concentration of carbopol and propylene glycol was 1.04% and 7.85%, 1832.42 ± 62.48 cP viscosity, 5.96 ± 0.08 cm spreadability, 64.63 ± 0.97 seconds of adhesion, and pH 5.26 ± 0.03. The antibacterial test showed an inhibitory power with 28.67 ± 0.76 mm. From the teat result, it can be concluded that the gel had antibacterial activity and good physical properties.
Co-Authors Akbar Rino Pamuladiman Aprilia Kusbandari Artika Tri Oktafiani Azis Ikhsanudin Citra Ariani Edityaningrum Deasy Vanda Pertiwi Dewa Ayu Arimurni Endah Prastyaningrum Feby Zulien Fitri Ulfani Kintoko, Kintoko Noorlina Noorlina Noorlina, Noorlina Widyasari Putranti